Surgical Outcome of Endoscopic Endonasal Surgery for Non-Functional Pituitary Adenoma by a Team of Neurosurgeons and Otolaryngologists
AIM: This study aimed to assess the efficacy of endoscopic endonasal surgery, conducted by a team of neurosurgeons and
MATERIAL and METHODS: We studied 40 patients who were undergoing surgery for primary non-functional pituitary adenomas
with Knosp grades 1 to 3, at Keio University Hospital between 2005 and 2012. We compared the endoscopic endonasal
transsphenoidal approach (team-eTSS; T-eTSS), with a microscopic transsphenoidal approach (mTSS). Analyses were conducted
for differences between the two groups in tumor resection rates, operating durations, and complications from the non-functional
pituitary adenomas. We also compared the heminostril and binostril approaches for T-eTSS.
RESULTS: Tumor resection rates were higher when the surgeries were conducted by T-eTSS than mTSS. In particular, when the
maximum tumor diameter was more than 25 mm, resection rates were significantly higher for T-eTSS than for mTSS. There were
no unexpected complications in either group. There was no significant difference in resection rates between the heminostril and
binostril approaches when T-eTSS was performed.
CONCLUSION: T-eTSS is an efficacious surgical option for non-functional pituitary adenomas, particularly when the adenoma is of
large size. Benefits of the heminostril approach are evident.