Searching Evidences of Stroke in Animal Models: A Review of Discrepancies A Review of Discrepancies
1Anadolu Medical Center, Department of Neurological Sciences, Istanbul, Turkey
2Maltepe University, Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey
So far, animal models have helped us better understand the pathophysiology of the ischemic brain damage but they could not
contribute so much to clinical practice. The discrepancies in results regarding neuroprotective agents in animal experiments compared
to clinical trials have not been solved. Various animal models of ischemic stroke have proven efficacy of many neuroprotective
agents without any considerable result in phase III clinical trials.
As is well known, stroke-related focal cerebral ischemia or cardiac arrest related global cerebral ischemia are major causes of
disability and death among human subjects. Animal models are essential to evaluate the therapeutic approaches for humans.
In this review, we will try to answer two important questions: 1) Which factors endanger the reliability of experimental studies of
stroke on animal models? 2) How can we design our experiments to reflect the neurorestoration and/or neuroprotection mechanisms
following ischemic injury, when it comes to human disease?
Stroke, Animal models, Discrepancies