Turkish Neurosurgery
EFFECTS OF 4% ICODEXTRIN ON EXPERIMENTAL SPINAL EPIDURAL FIBROSIS
Turker KARANCI1, Bilal KELTEN2, Alper KARAOGLAN2, Nilgun CINAR3, Ahmet MIDI3, Veysel ANTAR1, Hidayet AKDEMIR1, Zeynep Mine Yalçınkaya KARA1
1Medıcana Internatıonal Istanbul Hospıtal, Department of Neurosurgery, istanbul,
2maltepe university, department of neurosurgery, istanbul,
3maltepe university, Department of Neurology, istanbul,
DOI: 10.5137/1019-5149.JTN.15079-15.1
Aim:The aim of this experimental study is to investigate whether spinal epidural 4% glucose polymer solution is effective in the prevention of fibrosis with postoperative.Material and Methods:Twenty eight adult Wistar albino rats were randomly divided into two equal groups, including treatment and control. Both groups underwent L1 vertebral total laminectomy to expose the dura. Topical treatment group received % 4 icodextrin. Four weeks later, epidural fibrosis was examined in both groups histologically, biochemically and macroscopically.Results:Our study suggest that topical use of % 4 icodextrin prevents significantly epidural fibrosis following the laminectomy operation.Conclusion:Topical 4% icodextrin application inhibits post-operative epidural fibrosis with various mechanisms and prevents adhesions by playing barrier role between tissue surfaces through flotation. Our study is first to present the evidence of experimental epidural fibrosis prevention with 4% icodextrin
Corresponding author : Turker KARANCI