Aim:Spinal cord injury (SCI) is a devastating condition of the central nervous system. Today any therapeutic agent has not been proved to heal this complex condition yet. Asiatic acid (AA), which has been used in the far Eastern countries as an anti-inflammatory agent, antioxidant and wound healing therapeutic for years. We investigated efficiency of AA administration just after spinal cord injury in rats.Material and Methods:Adult male Sprague-Dawley rats ( n =32) were drafted in to Four experimental groups (Laminectomy, Laminectomy+ Trauma, Vehicle, AA) ramdomly.By Modified Allen’s weight-drop technique spinal cord trauma achived. Proinflammatory cytokines (IL-6, IL1-β, TNF-α), lipid peroxidation (MDA) levels and Tarlov functional recovery assessment scores were evaluated. Results:We performed 1-way ANOVA test for the analysis of the difference between 4 experimental groups and groups were compared individually by Tukey-LSD post hoc analysis test (P=0,001). AA administration just after SCI attenuates the levels of lipid peroxidation (MDA levels), proinflammatory cytokines (TNF-α, IL1β) and increases the Tarlov Scores.Conclusion:As a result, we conclude that AA supplementation could attenuate a number of deleterious reactions that are triggered after traumatic SCI. More investigations should be harvested on the neuroprotective effects of AA supplementation after trauma.