Turkish Neurosurgery
NERVE TİSSUE PREFABRİCATİON İNSİDE THE RAT FEMORAL BONE: DOES İT WORK?
Zühtü Özbek1, Atacan Emre Koçman2, Orhan Özatik3, Erdem Söztutar4, Emre Özkara1, Aydan Köse2, Ali Arslantaş1, Cengiz Çetin2
1Eskisehir Osmangazi University Medical Faculty , Neurosurgery, Eskişehir,
2Eskisehir Osmangazi University Medical Faculty , Plastic Surgery, Eskişehir,
3Ahi Evran University Medical Faculty , Histology and Embryology, Kırşehir,
4Eskisehir Osmangazi University Medical Faculty , Anatomy, Eskişehir,
DOI: 10.5137/1019-5149.JTN.16604-15.0

Aim:This study was aimed to investigate whether nerve regeneration can be induced in the tubular bone between distal and proximal cut nerve ends. Material and Methods:Twenty adult Wistar rats were used for the study. Rats were divided in three groups; femoral bone conduit group, nerve transection group, sham group. Sciatic nerve was surgically cut and from both ends inserted into the adjacent femoral bone tunnel at femoral bone conduit group. The sciatic nerve was cut transversely at nerve transection group. In Sham group; only sciatic nerve exploration was performed, without nerve cut. Groups were evaluated functionally and morphologically.Results:All results showed that axonal growth existed through the osseous canal. Conclusion:To the best of our knowledge, this is the first study to evaluate the neural regeneration inside the bone. We can speculate that the bone marrow provides a convenient microenvironment for peripheral nerve regeneration. In addition to prefabricating peripheral nerves, this novel model may help to establish further strategies for engineering of other tissues in the bone marrow.

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