Turkish Neurosurgery
RESVERATROL TREATMENT PREVENTS HIPPOCAMAL NEURODEGENERATION IN A RODENT MODEL OF TRAUMATIC BRAIN INJURY
Tugay Atalay1, Ismail Gulsen2, Nese Colcimen3, Hamit Hakan Alp4, Enver Sosuncu 5, Ilker Alaca 6, Hakan Ak 1, Murat Cetin Ragbetli 3
1Bozok University, School of Medicine, Department of Neurosurgery , Yozgat,
2Yuzuncuyıl University, Department of Neurosurgery , Van,
3Yuzuncuyıl University, Department of Histology and Embryology, Van,
4Yuzuncuyıl University, Department of Biochemistry, Van,
5Ercis state Hospital, Department of Neurosurgery , Van,
6Yuksekova State Hospital, Department of Neurosurgery , Hakkari,
DOI: 10.5137/1019-5149.JTN.17249-16.2

Aim:Traumatic brain injury (TBI) is a complex process that increasing evidence has demonstrated that reactive oxygen species contribute to brain injury. Revesterol (RVT), which exhibits significant antioxidant properties, is neuroprotective against excitotoxicity, ischemia, and hypoxia. Our aim was to evaluate the neuroprotective effects of RVT on the hippocampus in a rat model of TBI.Material and Methods:Seven rats were divided into four. A moderate degree of head trauma was induced using Feeney’s falling weight technique. Group1 (control) underwent no intervention. Head trauma was induced in the Group 2 (trauma) and, no drug was administered. Head trauma was induced in the Group 3 rats and low-dose RVT (50 mg/kg per day) was injected and in the fourth group, high-dose RVT (100 mg/kg per day) was used. Brain tissues were extracted immediately after perfusion without damaging the tissues. Histopathological and biochemistry parameters were studied.Results:Brain tissue malondialdehyde (MDA) levels in the trauma group were significantly higher than those in the control, low-dose RVT-treated, and high-dose-RVT-treated groups. The superoxide dismutase (SOD) levels in the control group were significantly higher than those in the trauma, low-dose RVT-treated, and high-dose RVT-treated groups. Glutathione peroxidase (GSH-Px) levels in the control group were significantly higher than those in the trauma and low-dose RVT-treated groups. The level of oxidative DNA damage (8-OHdG/106 dG) in the trauma group was higher than that in the control group, low-dose RVT-treated, and high-dose RVT-treated groups. Conclusion:Our results demonstrated that RVT had a healing effect on neurons after TBI.

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