Turkish Neurosurgery
Comparison of the effects and mechanism of the Curcumin with different acting drugs in Experimental Vasospasm after Subarachnoid Hemorrhage
Hasan Emre Aydın1, Nuriye Ezgi Bektur2, Zuhtu Ozbek3, Setenay Oner4, Cengiz Baycu2, Fatma Sultan Kılıç5
1Yunus Emre State Hospital, Neurosurgery, Eskişehir,
2Osmangazi University, Histology, Eskişehir,
3Osmangazi University, Neurosurgery, Eskişehir,
4Osmangazi University, Biostatistic, Eskişehir,
5Osmangazi University, Pharmacology, Eskişehir,
DOI: 10.5137/1019-5149.JTN.17432-16.2

Aim:Cerebral vasospasm following subarachnoid hemorrhage (SAH) is the most important complication which effects mortality and morbidity of patients with intracranial aneurysm although effective treatment. Today, the mechanisms of vasospasm is not understood in spite of experimetal and clinical researches. The aim of our study to investigate the effect of curcumin which used in medical treatment of some illness and known antioxidant drug on vasospasm following SAH. Material and Methods:In this study, 200-250 gr weight and 64 rats were divided into 7 groups. Group 1, having no treatment after SAH; Group 2, treatment with nimodipin after SAH; Group 3, treatment with nicorandil after SAH; Group 4, treatment with sildenafil sitrat after SAH; Group 5, treatment with curcumin 150 mg/kg after SAH; Group 6, treatment with curcumin 300 mg/kg after SAH, Group 7, treatment with curcumin 600 mg/kg after SAH. The experimental SAH was induced by injection of autologous blood taken from hearth into the cisterna magna. After medical treatment, in the 1. hour, take blood for quantified the levels of TNFα, IL1β and IL6. Than, cerebrum and cerebellum excised totaly with craniectomy. Results:Basilar artery lumen diameter and apoptotic cell count performed with tissue samples. Histopathological findings showed that, in sufficent dose, curcumin dilated basilar artery beside antioxidant effect.Conclusion:Because of these properties, curcumin can be used for treatment of vasospasm as a new medical drug.

Corresponding author : Hasan Emre Aydın