Presented study aims to describe the relation between the parenchymal pressure changes and the development of hydrocephalus regarding the cerebral regions and dates, in kaolin injected neonatal rats.
Material and Methods:
Neonatal rats of 2 to 3-day-old were divided in 5 groups as; kaolin frontal K-F, kaolin parietal K-P, saline frontal SF-F, saline parietal SF-P and control C based on the injected material and injection sites. All injections were made to cortical subarachnoid space of right frontal and right parietal regions. No injection was made to group 5 rats. On 3rd, 7th, 15th, 30th and 60th days post injection, parenchymal pressures (PP) of 5-7 rats from each group were measured from different regions.Results:
We compared control groups with saline injected and kaolin injected groups and found statistically significant parenchymal pressure differences based on regional measurements. In kaolin groups the mean PP values were detected obviously high than saline injected groups. Within each kaolin injected group, the pressure values were variable and inconsistent regarding the parenchymal regions.
Our efforts to concentrate on the pathogenesis of hydrocephalus in the light of regional parenchymal pressure inconsistency, led us to conclude that hydrocephalus cannot be totally enlightened with existent bulk-flow or hydrodynamic theories. Although our experimental design was planned to develop hydrocephalus according to bulk flow theory, our results were more compatible with hydrodynamic theory. The present comments on the occurrence and pathogenesis of hydrocephalus are still open to debate and may require further comprehensive studies.