Turkish Neurosurgery
Antiepileptic drugs for patients with intracerebral hemorrhage — a meta analysis
zhong yao1, lu ma1, chao you1
1West China hospital of sichuan university, neurosurgery, chengdu,
DOI: 10.5137/1019-5149.JTN.18791-16.2

OBJECTIVE Whether antiepileptic drug (AED) should be prescribed for intracerebral hemorrhage (ICH) patients is a matter in dispute, and recent studies have come up with different or even opposite views. A meta-analysis on this issue has not been performed. The goal of this meta-analysis is to study the antiepileptic drugs’ effects on early seizure occurrence and outcome for ICH patients. METHODS We searched the PubMed, Ovid, and Cochrane library until December 2015 to identify relevant articles. Meta analysis was conducted to evaluated the overall effect with random-effects or fixed-effects models. RESULTS Four articles met the included criteria, one randomized controlled trial and three cohort studies. For the occurrence of early seizure, antiepileptic drugs showed ability to reduce the risk, but reached no statistical significance (OR=0.71; 95% CI, 0.38-1.34; test for overall effect Z=1.06, p=0.29). No association between antiepileptic drug use and poor outcome was found(OR=1.95; 95%CI, 0.56-6.79; test for overall effect Z=1.06, P=0.29), but there exited heterogeneity. CONCLUSIONS Summarizing published studies, the AED use did not reduce early seizure occurrence statistically, however population with high risk factors of early seizure is likely to benefit from AEDs. Besides AED was not associated with poor outcome. We suggest AED use for ICH patients with high risk factor of seizure, not generally.

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