Turkish Neurosurgery
Effects of Arginine Vasopressin and V1 receptor antagonist on Cerebral Vasospasm Secondary to Subarachnoid Hemorrhage: An Experimental Study
Derviş Mansuri Yılmaz1, Ersin Hacıyakupoğlu2, Serkan Diril1, Leman Sencar3, Erol Akgül4, Sait Polat3, Sebahattin Hacıyakupoğlu5, Ersin Nazlıcan6
1Cukurova University, School of Medicine, Neurosurgery, Adana,
2Umraniye Education and Research Hospital, Neurosurgery, İstanbul,
3Cukurova University School of Medicine, Histology and Embryology, Adana,
4Cukurova University School of Medicine, Radiology, Adana,
5Acibadem University School of Medicine, Neurosurgery, Adana,
6Cukurova University School of Medicine, Public Health, Adana,
DOI: 10.5137/1019-5149.JTN.19283-16.3
Aim:The aim of this study is to examine morphological, radiological and biochemical effects of arginine vasopressin(AV) and AV V1 receptor antagonist cerebral vasospasm(CVS) in rabbit subarachnoid hemorrhage(SAH). Material and Methods:Forty male New Zealand white rabbits were randomly divided to four groups comprising 10 rabbits each. The groups were 1) control, 2) subarachnoid hemorrhage(SAH), 3) SAH+AV application, 4) SAH+V1 antagonist of AV V1 receptor Diameters of the basilar artery of all the groups were measured on angiograms. All the animals were sacrified two days following basilar angiography and tissue samples of basilar artery was dissected under microscope after immediate craniectomy for ultra structural and biochemical examination. Results:The artery diameters were found to be 50% and 50% at the 30th minute in the groups 2 and 3 respectively. In group 3, Cerebral vasospasm (CVS) was 13% more in comparison with the 2nd group. In group 4, vascular constriction was 34.5% at the 30th minute and about 30.9% at the 300th minute. Despite the increase in regional blood circulation, AV did not provide morphologic change. Histologic appearance was related to vascular stenosis due to CVS Histological outlook was the best in group 4 because of less often CVS. Conclusion:Arginine vasopressin plays an important role in CVS. We detected morphologic and radiological recovery in basilar artery, besides moderate improvement due to AV receptor antagonist in CVS.
Corresponding author : Derviş Mansuri Yılmaz