Turkish Neurosurgery
Neuroprotective Effects of Oleocanthal, A Compound in Virgin Olive Oil, in A Rat Model of Traumatic Brain Injury
Mesut Mete1, Isıl Aydemir2, Ulkun Unlu UNSAL6, Fatih Collu3, Gökhan Vatandas1, Beyhan Gurcu3, Yusuf Kurtulus Duransoy1, Fatma Taneli5, Mehmet Ibrahim Tugrul4, Mehmet Selcuki1
1Celal Bayar University School of Medicine Neurosurgery Department, Neurosurgery, Manisa,
2Ömer Halisdemir University School of Medicine , Histology and Embryology, Niğde,
3Celal Bayar University Faculty of Science and Letters Zoology Section, Biology, Manisa,
4Celal Bayar University School of Medicine , Histology and Embryology, Manisa,
5Celal Bayar University School of Medicine , Biochemistry, Manisa,
6Koc University School of Medicine , Neurosurgery, Istanbul,
DOI: 10.5137/1019-5149.JTN.21417-17.2
Aim:TBI has two distinct phases: primary and secondary injury. Many agents have been used to prevent secondary injury. Oleocanthal (OC) has anti-inflammatory and antioxidant properties similar nonsteroidal anti-inflammatory drug. We evaluated the neuroprotective effects of OC in a rat model of TBI.Material and Methods:Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. group 1, sham (n = 5). group 2, trauma (n = 5): Rats were treated with 10 mg/kg saline intraperitoneally (IP) twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n = 8) or 30 (group 4, n = 8) mg/kg OC IP twice a day. For each group brain samples were collected 72 h after injury. Brain samples and blood were evaluated with histopathological and biochemical methods.Results:Histopathological evaluation revealed a significant difference between group 2 and group 4. Biochemical findings demonstrated that, oxidative stress index was the highest in group 2 and was the lowest in the group 4. Conclusion:Results indicated that OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress and apoptosis.
Corresponding author : Mesut Mete