AIM: This study aimed to study the protective effect of intraoperative awakening and central sulcus location on motor function for patients with gliomas located in motor areas. METHODS: A total of 68 patients with gliomas in motor areas were intubated with a laryngeal mask and rapidly underwent craniotomy without scalp clips and awakening, followed by localization of the central sulcus by somatosensory evoked potential. To protect brain function, we resected the greatest degree of tumor as possible and then finished the close-skull under an awakened state or general anesthesia. RESULTS: All the patients underwent operation successfully. Except for the emergence of new nervous dysfunction in six patients, most patients’ neurological functions did not deteriorate or even showed improvements. In addition, there were no complications or postoperative painful memories for the patients. Resection of gliomas in motor areas with intraoperative awakening and localization of central sulcus can ensure the largest possible resection of the tumor while protecting brain function. CONCLUSION: Here, we describe a simple and effective surgical procedure for the operation of the central sulcus and awakening during operation. The technique of localizing the central sulcus under awakening anesthesia can improve the prognosis for patients with gliomas in motor areas.