Turkish Neurosurgery
Effects of Resveratrol on Inflammation and Apoptosis after Experimental Spinal Cord Injury
Salim Senturk1, Mesut Emre Yaman2, Hasan Emre Aydin3, Guven Guney4, Ismail Bozkurt5, Kemal Paksoy6, Ahmet Atilla Abdioglu7
1Koc University Hospital, Neurosurgery, Istanbul,
2Memorial Hospital, Neurosurgery, Ankara,
3Dumlupinar University, Neurosurgery, Kutahya,
4Hitit University Research and Training Hospital, Pathology, Corum,
5Cankiri State Hospital, Neurosurgery, Cankiri,
6Kackar State Hospital, Neurosurgery, Rize,
7Recep Tayyip Erdogan University, Orthopaedic Surgery, Rize,
DOI: 10.5137/1019-5149.JTN.21829-17.3

Aim:Reversing the disastrous effects spinal cord injury has become the most prominent topic of neuroscience. Although many therapeutic interventions are being examined, there is yet no definitive cure for spinal cord injury (SCI). In view of this, an experimental study on rats after spinal trauma was performed to test the effects of a natural phenol; Resveratrol.Material and Methods:18 Sprague Dawley rats were randomly divided into three groups. All groups underwent thoracic laminectomy. The first group received no other intervention. The second and third group suffered SCI via aneurysm clip method. The third group received Resveratrol. After sacrificing the rats, immunohistochemical analysis along with biochemical parameters of TNF-α and IL 1β were measured.Results:Resveratrol receiving group had statistically significant lower levels of TNF-α, IL 1β, TUNEL positive cells and higher number of glial and motor neuron cells.Conclusion:It is this experiment’s conclusion that along with proven cardioprotective effects of Resveratrol, it proves to have significant neuroprotective effects on SCI in an experimental model.

Corresponding author : Ismail Bozkurt