Turkish Neurosurgery
Characterizing the intraoperative microelectrode recording-induced microlesion effect on motor symptoms in patients with Parkinson′s Disease undergoing deep brain stimulation of the subthalamic nucleus
Dursun Aygün1, Ümit Akın Dere5, Onur Yıldız1, Yasin Temel2, Ersoy Kocabıçak4
1Ondokuz Mayıs University, Department of Neurology, Samsun,
2Maastricht University, Department of Neurosurgery , Maastricht,
3Maastricht University, Department of Translational Neuroscience, Maastricht,
4Ondokuz Mayıs University, Department of Neurosurgery , Samsun,
5Başkent Univeristy, Department of Neurosurgery , Ankara,
DOI: 10.5137/1019-5149.JTN.24348-18.3

Aim:Deep brain stimulation (DBS) of the subthalamic nucleus is a preferred option for the treatment of motor symptoms in patients with Parkinson\'s disease (PD). Intraoperative microelectrode recording (MER), which guides the implantation of the DBS lead, can induce a microlesion effect (MLE) that results in motor symptom improvement. Although this phenomenon is well known, its quantitative impact remains unknown. In this prospective study, we investigated MER-induced MLE on the motor symptoms of 30 patients with PD.Material and Methods:MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation.Results:MLE scores improved by 21.7% [left (L) side] and by 13.6% [right (R) side] from baseline (p < 0.05). Tremor scores improved by 31.5% (L) and by 14.2% (R) (p < 0.05), rigidity scores improved by 17.3% (L) and by 14.2% (R) (p < 0.05) and bradykinesia scores improved by 20.6% (L) and by 11.5% (R) (p < 0.05) from baseline. There was no significant difference between MLE and the number of microelectrodes used (p > 0.05).Conclusion:MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure.

Corresponding author : Ümit Akın Dere