Turkish Neurosurgery
EFFECT OF CURCUMINE ON THE FORMATION OF EPIDURAL FIBROSIS IN AN EXPERIMENTAL LAMINECTOMY MODEL IN RATS
Özgür İsmailoğlu1, Zahir Kızılay2, Nesibe Kahraman Çetin3, Abdullah Topçu2, Osman Berber2
1Süleyman Demirel University Medical Faculty Hospital, Neurosurgery, Isparta,
2Adnan Menderes University, Faculty of Medicine, Neurosurgery, Aydın,
3 Adnan Menderes University, Faculty of Medicine, Pathology, Aydın,
DOI: 10.5137/1019-5149.JTN.24773-18.1
Aim:To clarify the effects of topical application of curcumin on the prevention of epidural fibrosisMaterial and Methods:Twenty-one rats were randomly divided into three equal groups (control, Spongostan, local curcumin) and laminectomy procedure was performed between T11 and L1 in all rats. Subsequently, curcumin (100 mg/kg) was applied topically as soaked in Spongostan; After four weeks, the vertebral column from T9 to L3, which include the paraspinal muscles and epidural scar tissue were removed single piece and epidural fibrosis and arachnoidal scarring was graded and histopathological analysis was carried out accordingly. Kruskal-Wallis and Pearson Chi-Square tests were used for statistical with a significance level of p < 0.05.Results:The grading of epidural fibrosis was far lower in the experiment group curcumin compared to those of control and spongostan groups but this difference was not statistically significant. Conclusion:The findings of this study show that local curcumin lowers the formation of epidural fibrosis and that this effect of curcumin thought to mediated by reducing the functions of inflammatory cells such as macrophages, neutrophils and fibroblasts, including anti-inflammatory and antioxidant effects
Corresponding author : Özgür İsmailoğlu