Turkish Neurosurgery
XCR1 Expression Profile of Surgically Resected Astroytomas
Fatih Erdi 1, Fatih Keskin1, Emir Kaan Izci2, Bulent Kaya3, Yasar Karatas 3, Bahadır Feyzioglu4, Sıddıka Fındık5, Erdal Kalkan3, Hasan Esen5, Yalcın Kocaogullar1
1Necmettin Erbakan University Meram Medicine Faculty, Neurosurgery, Konya,
2Konya Meram Educational Research Hospital, Neurosurgery, Konya,
3Medova Hospital, Neurosurgery, Konya,
4Necmettin Erbakan University Meram Medicine Faculty, Microbiology, Konya,
5Necmettin Erbakan University Meram Medicine Faculty, Pathology, Konya,
DOI: 10.5137/1019-5149.JTN.25092-18.2

Aim:A selective group of human dendritic cells (DCs) can express a special chemokine receptor, XC chemokine receptor 1 (XCR1), which has been reported to be associated with the proliferation and migration of cells of certain cancers. Currently, there is no information about the XCR1 expression profile of astrocytoma. In this study, we examined XCR1 expression in human astrocytoma tissue samples from patients with different grades of the tumor.Material and Methods:Formalin-fixed, paraffin-embedded astrocytoma samples were obtained from 40 patients. Histopathological examination, typing and grading were reevaluated. The study group included 10 histologically normal brain tissue samples, which served as the control group, and 10 World Health Organization (WHO) grade II, 10 WHO grade III, and 10 WHO grade IV (glioblastoma) tumor samples. Normal brain tissue samples were obtained from the histologically normal non-tumoral portion of the pathology specimens. XCR1expression was evaluated using quantitative reverse transcription–polymerase chain reaction and immunohistochemistry. Results:Compared with the control group tissue, XCR1 was overexpressed in astrocytoma tissues. Furthermore, XCR1overexpression was significantly increased according to the ascending grades of astrocytoma from grade II to IV tumor samples.Conclusion:XCR1 might be a good target for understanding the interaction between the underlying mechanisms of astrocytoma formation–progression and the existing immune response.

Corresponding author : Emir Kaan Izci