Aim:To determine the relationship between the serum urate (SU) level,neutrophil/lymphocyte ratio (NLR), andpain severity using preoperative and postoperativevisual analogue scale (VAS) scores in patients with lumbar disc hernia (LDH). Material and Methods:This single-center, cross-sectional study included 20 consecutive patients who were operated for LDHby the same surgeon. The patients’pre- and postoperative UA levels,NLRs, and intensityseverity VASscores were investigated.Preoperative magnetic resonance imaging (MRI) findings, serum UA levels, and neutrophil and lymphocyte counts were recorded. The herniated disc volume at the L4-5 level on preoperative MRI was similar in all patients. Pain severity was recorded preoperatively and at 6 months postoperatively. Effects of the preoperative SU levels and NLRs on the pre- and postoperative VAS scores were statistically assessed.Results:Statistically significant positive correlation coefficients were determined between NLR and the preoperative and postoperative VAS scores. Negative correlation coefficients were found betweenthe SU levels and preoperative VAS scores;in contrast, positive correlation coefficients were found between the SU levels and the postoperative VAS scores.Conclusion:Our results demonstrate the importance of not ignoring the serum UA level and NLR in pre- and postoperativepain in patients with LDH. Nevertheless, further extensive studies are warranted.