Turkish Neurosurgery
Use of muscle graft versus fascia flap as interpositional material in prevention of reossification in a rat model of skull bone defect
Ayhan Okumuş1, Erdem Güven1, Ismail Ermis1, Vakur Olgaç2, Murat Topalan2, Metin Erer2
1Istanbul University Istanbul Faculty of Medicine, Department of Plastic Surgery, İstanbul,
2Istanbul University Oncology Institute, Division of Tumor Pathology, İstanbul,
DOI: 10.5137/1019-5149.JTN.26466-19.2
Aim:This study was design to investigate the utility of two different interpositional materials (muscle graft vs. fascia flap) in prevention of osseous reunion of skull bone defect including coronal suture line in rats. Material and Methods:: A total of 32 male Sprague-Dawley rats were separated into 2 groups (n=16 for each) after formation of bilateral coronal bone defect, with respect to interpositional materials used to prevent reossification including muscle graft (MG group) and fascial flap (FF group). In each group, the other side of the coronal suture served as a control. Rats were sacrificed at 4 weeks or 8 weeks after surgery to perform histopathological, radiological, and microbiologic investigations.Results:At the 8th postoperative week, there was partial reunion in the defects with bony tissue in MG and FF groups and no obvious differences were noted between the groups radiologically. Defect content involved bone and fibrous tissue in the MG group and bony bridges and loose connective tissue in the FF group. New bone formation was moderate, marked and extreme in MG, FF and control groups, along with marked, moderate, and extreme decrease in defect size, respectively. Conclusion:Our findings revealed that neither the temporal muscle graft nor the temporal fascial flap resulted in complete prevention of re-ossification of the skull bone defects including the coronal suture line along with no superiority of one material over the other.
Corresponding author : Ayhan Okumuş