Turkish Neurosurgery
Comparison of Immunogenetic Properties of Glial Tumors with Advanced Magnetic Resonance Imaging Findings
Burak Gezer1, Ali Mutlukan2, Mert Sahinoglu3, Pinar Karabagli4, Ender Koktekir3, Hakan Karabagli3
1Tatvan State Hospital, Neurosurgery, Bitlis,
2Serik State Hospital, Neurosurgery, Antalya,
3Selcuk University, Neurosurgery, Konya,
4Selcuk University, Pathology, Konya,
DOI: 10.5137/1019-5149.JTN.27261-19.3
Aim:To investigate the immunogenetic properties of glial tumors with using preoperative advanced magnetic resonance (MR)technique findings.Material and Methods:This study included 64 males and 50 females who had diagnosed glial tumor. MR spectroscopy (MRS), MR perfusion (PWI), and MR diffusion (DWI) were performed in 50 patients preoperatively. Results:Among the patients included in the study, 25 were grade II (21.9%), 26 grade III (22.8%), and 63 grade IV (55.3%). All patients were IDH1 stained: 47 were IDH mutant (41.2%) and 67 were IDH wild-type (58.8%). A statistically significant difference in the survival time was observed between IDH mutant and wild type. A significant difference in PWI relative cerebral blood volume (rCBV) and DWI apparent diffusion coefficient coefficients was noted among grade II, III, and IV tumor groups. The PWI rCBV cutoff value for grade IV tumors was 2.05(90% sensitivity, 78% specificity).No difference in the Cho/Cr ratio among grade II, III, and IV tumor groups was noted. A significant difference was noted between the IDH mutant and wild type in terms of PWI rCBV and Ki-67 proliferation values. The PWI rCBV cutoff value of IDH mutant–wild type was 2.15. The Ki-67 proliferation cutoff value of IDH mutant–wild type was 11%. No difference in the Cho/Cr, Cho/NAA, and DWI apparent diffusion coefficients (p> 0.05)was noted between the IDH mutant and wild type.Conclusion:PWI rCBV is the most important prognostic value of aMRI used in tumor grading. No correlation between Cho/Cr and Cho/NAA ratios and tumor grading was seen.PWI rCBV values could be significant in distinguishing these two types.
Corresponding author : Ender Koktekir