Turkish Neurosurgery
The analysis of safety and effectiveness of using allografts in the treatment of spinal tuberculosis-A multicentre retrospective study
Yang Sen1, Wu Wenjie1, Luo Fei1, Zhang Zehua1
1The First Affiliated Hospital of Army Medical University, PLA, Orthopaedics, Chongqing,
DOI: 10.5137/1019-5149.JTN.27503-19.3
Aim:To evaluate the clinical efficacy and fusion characteristics of allografts in spinal tuberculosis (TB).Material and Methods:The research reviewed 1196 patients with spinal tuberculosis who received treatment at six hospitals from January 2000 to January 2016. A total of 623 patients who had spinal tuberculosis were included in the study. All patients underwent debridement, decompression, allograft bone grafting, and instrumentation. Postoperative treatment consisted of a combination of anti-TB drug treatment for 18 months and brace fixed braking for 3–9 months. Clinical outcome, laboratory indexes, and radiological results were analysed.Results:The average follow-up time was 34.1 months (12–60 months). Pain was relieved postoperatively in all cases, and 87.8% of patients were painless at the final follow-up. The erythrocyte sedimentation rate (ESR) significantly decreased and returned to normal at the final follow-up. The fusion rate of allografts was 30.2% and 98.4% at the 9- and 12-month follow-ups, respectively. At the final follow-up, the fusion rate was 100%.Conclusion:The application of allografts in the surgical management of spinal tuberculosis is safe and effective. Allografts can replace autografts in surgeries for spinal tuberculosis.
Corresponding author : Zhang Zehua