Turkish Neurosurgery
Analyses of copy number variations in myxopapillary ependymomas of cauda equina
Ali Ozen1, Fatih Bayrakli2, Ozcan Sonmez2, Irem Peker Eyuboglu4, Onur Erdogan2, Can Erzik4, Mustafa Cengiz Yakicier5, Suheyla Uyar Bozkurt6
1Adıyaman University Research and Education Hospital, Neurosurgery, Adıyaman,
2Marmara University Medicine Faculty, Neurosurgery, İstanbul,
3Marmara University Institute of Neurological Sciences, Neurosurgery, İstanbul,
4Marmara University Medicine Faculty, Medicine Biology, İstanbul,
5Acibadem University Faculty of Arts and Sciences, Molecular Biology and Genetics, İstanbul,
6Marmara University Medicine Faculty, Pathology, İstanbul,
DOI: 10.5137/1019-5149.JTN.28129-19.1

Aim:We aimed to identify copy number variations that are specific to myxopapillary ependymomas (MPEs) of the cauda equina.Material and Methods:The patient cohort included five patients who underwent resection of histologically confirmed MPEs. Tumor samples collected during surgery and stored in liquid nitrogen as well as corresponding blood samples collected were analyzed. Genomic DNA from the venous blood and tumor samples was obtained using standard techniques and hybridized to a Cytoscan 750K Array in accordance with the manufacturer’s introductions.Results:As a novel finding, amplification on chromosome 14q32.33 was detected in all tumor and blood samples, except one tumor sample. All tumor tissues also showed amplification on chromosomes 5, 7, 9, and 16.Conclusion:Although further studies with larger cohorts are required to identify genes involved in MPE tumorigenesis and to validate our results, these findings provide a basis for advanced molecular biological and genetic studies of MPEs.

Corresponding author : Fatih Bayrakli