Turkish Neurosurgery
Relationship Between Vasospasm and Serum Chromogranin A Levels in an Animal Subarachnoid Haemorrhage Model
Halil Can Küçükyıldız1, Salih Kürşat Şimşek2, Almila Şenat4, Ahmet Gürhan Gürçay3, Ceylan Bal4, Ercan Bal3
1Tokat State Hospital, Neurosurgery, TOKAT,
2Ankara City Hospital, Neurosurgery, ANKARA,
3Yıldırım Beyazıt University Faculty of Medicine, Neurosurgery, ANKARA,
4Yıldırım Beyazıt University Faculty of Medicine, Biochemistry, ANKARA,
DOI: 10.5137/1019-5149.JTN.28235-19.5
Aim:In that study, searching Chromogranin A levels on vasospasm in experimental subarachnoid heamorrhage (SAH) model was aimed.Material and Methods:Sixteen Wistar Albino male rats were used in study. Two groups are formed; first was consisting of 8 rats that experimental SAH was performed on them, second group was control group that nothing was done. Animals were sacrified fourtyeight hours later subarachnoid heamorrhage was occured. Peripheral venous blood samples were taken from the experimental group before SAH formation, 15 minutes, 75 minutes after experimental SAH formation and 48 hours as peak of vasospasm. Simultaneous peripheral venous blood samples were also collected from the control group. Blood samples were biochemically evaluated after centrifugation and serum Chromogranin A levels were studied.Results:Serum chromogranin A levels increased statistically significant (p<0,05) at the 15th minute after SAH, as the samples obtained from the experimental and control groups were anticipated as a result of the statistical analysis of the data after the biochemical examinations.Conclusion:In all these findings, we concluded that Chromogranin A could be used as a marker for the investigation of endocrine stress in the early period of post-SAH vasospasm and it could be proved by more studies.
Corresponding author : Halil Can Küçükyıldız