Turkish Neurosurgery
Circulating Levels of Thrombospondin-1 and Thrombospondin-2 in Patients with Temporal Lobe Epilepsy Before and After Surgery
Orkhan Alizada1, Mehmet Yigit Akgun1, Ahmet Faruk Ozdemir1, Sureyya Toklu1, Rahsan Kemerdere1, Bagnu Orhan2, Berrin Bercik Inal2, Seher Naz Yeni3, Taner Tanriverdi1
1Cerrahpasa Medical Faculty, Neurosurgery, Istanbul,
2Istanbul Training and Research Hospital, Clinical Biochemistry, Istanbul,
3Istanbul University-Cerrahpasa, Neurology, Istanbul,
DOI: 10.5137/1019-5149.JTN.29081-20.4
Aim:This study measures the serum levels of strong angiostatic and synaptogenetic molecules thrombospondin-1 (TSP-1) and thrombospondin-2 (TSP-2) in patients with temporal lobe epilepsy (TLE) before and after surgery. Material and Methods:In this prospective study, 20 patients operated for TLE and 20 healthy subjects were included. Serum levels of TSP-1 and TSP-2 were measured using enzyme-linked immunosorbent assay (ELISA).Results: Our findings showed that both groups had higher serum levels of both molecules “before” surgery than 10 days “after” surgery. However, a significant difference was noted between “before” and “after” surgery regarding TSP-1 (p = 0.00001). Although a marked decrease was found “after” surgery with respect to TSP-2, the difference did not reach statistical significance (p = 0.22). In patients with TLE, serum levels of both molecules “before” surgery were found to be significantly higher than in healthy controls (TSP-1, p = 0.00001; TSP-2, p = 0.007). Conclusion:Serum levels of TSP-1 and TSP-2 are determined to be higher in patients with TLE than in healthy subjects, and the resection of epileptogenic tissues decreases the serum levels of these molecules. Future studies should involve a higher number of patients with serial serum levels of TSP-1 and TSP-2 at the long-term follow-up to correlate with seizure outcome.
Corresponding author : Taner Tanriverdi