Turkish Neurosurgery
Cytotoxic Effect Of Boron Application On Glioblastoma Cells
HASAN EMRE AYDIN1, MELİHA KOLDEMİR GÜNDÜZ2, CEREN KIZMAZOĞLU3, TURAN KANDEMİR4, ALİ ARSLANTAŞ5
1KUTAHYA UNIVERSITY OF HEALTH SCIENCES, NEUROSURGERY, KÜTAHYA,
2KUTAHYA UNIVERSITY OF HEALTH SCIENCES, MEDICAL SERVICES AND TECHNIQUES, KÜTAHYA,
3DOKUZ EYLUL UNIVERSITY, NEUROSURGERY, İZMİR,
4ESKİŞEHİR YUNUS EMRE STATE HOSPİTAL, NEUROSURGERY, ESKİŞEHİR,
5ESKIŞEHIR OSMANGAZI UNIVERSITY, NEUROSURGERY, ESKİŞEHİR,
DOI: 10.5137/1019-5149.JTN.30316-20.1
Aim:To investigate the cytotoxic effects of boron application at different doses on U-87 MG glioblastoma cellsMaterial and Methods:The T98G (ATCC® CRL-1690™) glioblastoma cell strain used in the study was acquired from the American Type Culture Collection (ATCC) (Manassas, USA). Boric acid solution was prepared by mechanical mixing in the medium. Afterwards, 2.5 mM, 25 mM and 50 mM boron were each added to U87-MG glioblastoma cells and incubated for 48 hours. The cytotoxic effects on the cells was determined using the MTT (Methylthiazole diphenyl tetrazolium) test 48 hours after boron application.Results:IC50 value was detected as 17 mM in the 48-hour boric acid application on U-87 MG glioblastoma cellsConclusion:Boron treatment might be an effective approach for glioblastoma
Corresponding author : TURAN KANDEMİR