Turkish Neurosurgery
Effect of Intravenous Tranexamic Acid on Intracerebral Brain Hemorrhage in Traumatic Brain Injury
Hosein Safari1, Parnian Farrahi1, Saleh Rasras1, Hosein Jafari Marandi1, Masoud Zeinali1
1Ahvaz Jundishapur University of Medical Sciences, Department of Neurosurgery, ahvaz,
DOI: 10.5137/1019-5149.JTN.30774-20.4

Aim:One of the main complications caused by traumatic brain injury (TBI) is intracerebral hemorrhage, and if we can somehow prevent the expansion of intracerebral hemorrhage, it reduces mortality and also the need for surgical intervention. This study aimed to determine the effect of Intravenous Tranexamic Acid (TXA) on a traumatic intracerebral hemorrhageMaterial and Methods:94 cases of TBI with intracerebral hemorrhage, admitted to the emergency department, who did not need surgical intervention, were randomly assigned into two groups of 47 patients. In the treatment group Intravenous TXA was administered every 6 hours for 48 hours, and in the control group, the placebo was administered in the same way. After 6, 24, and 48 hours all the cases underwent a brain CT scan. Scans were examined for the size and diameter of hematoma and the midline shift. The information regarding the level of consciousness, hematoma volume, and diameter on CT scan were recorded on arrival and 48h laterResults:Statistical results depicts that while there was no considerable difference in the demographic aspect of the two groups, volume and diameter of hematoma and the midline shift in the first CT scans and also their level of consciousness, the diameter and volume of hematoma and also the amount of hematoma expansion in follow up have significant differences in the two groups.Conclusion:This study showed that the prescription of TXA would reduce the amount of hematoma expansion in traumatic intracerebral hemorrhage, and the medicine can be introduced to reduce the morbidity and complications.

Corresponding author : Parnian Farrahi