Aim:Aim: In clinical assessments and literature conducted on TBI, the mild TBI is less studied, because the initial symptoms are non-specific and subjective, and have overlap with psychological disorders. Glial Fibrillary Acidic Protein (GFAP) is a protein expressed by most of the abundant cells of the CNS. Therefore, this paper attempted to show whether the GFAP levels are significantly higher in the serum of patients with mild traumatic brain injuryMaterial and Methods:The level of serum GFP was measured in 176 patients suffering from brain trauma. The ability of GFAP in predicting the presence of intracranial lesions and the need for neurosurgical intervention was analyzed using the area under the receiver (AUC) operating characteristic (ROC). By passing three months from mild TBI, the Post-Concussion Symptoms Questionnaire (PCSQ) as well as the physical and mental evaluations were performed using the SF-36 questionnaire.Results:Of 176 patients included, 79.5% had no complications and symptoms by passing three months from traumatic brain injury. The AUC for GFAP was 72.6%, which revealed a good accuracy in predicting the need for neurosurgical intervention. Conclusion:GFAP, as a predictive factor in people with mild TBI diagnosis who need neurosurgical operation, expressed a favorable diagnostic effect. Keywords: Mild TBI, GFAP, Neurosurgical operation