Turkish Neurosurgery
Effects of Quetiapine on Neural Tube Development in the Early Stage of Chicken Embryos
Talat Cem Ovalıoğlu1, Gokhan Canaz2, Sema Arslan3, Ayşegül Özdemir Ovalıoğlu1, Mehmet Sar4, Ayşegül Esen Aydın1, Erhan Emel1
1Bakirkoy Research and Training Hospital for Neurology, Neurosurgery and Psychiatry, Neurosurgery, Istanbul,
2Arnavutkoy State Hospital, Neurosurgery, Istanbul,
3Marmara University, Biochemistry, Istanbul,
4Bakırkoy Dr. Sadi Konuk Research and Training Hospital, Pathology, Istanbul,
DOI: 10.5137/1019-5149.JTN.32887-20.1

Aim:Quetiapine is the most used second-generation antipsychotic. It is commonly prescribed to pregnant women and its usage rate has been rising. This study aimed to investigate the effects of quetiapine exposure on neural tube development in early stage chicken embryos.Material and Methods:Eighty-four fertilised specific pathogen-free chicken eggs were divided into four equal groups (groups 1–4). Three experimental groups (groups 2, 3 and 4) and a single control group (group 1) were used. Each egg in group 2 (n = 21) was injected with 20 µL of saline after 30 h of incubation. Eggs in groups 3 and 4 were injected with 0.02 ml of a solution containing 400 and 800 µg of quetiapine dose, respectively. Incubation was continued until the end of 72 h. All embryos were then removed from the eggs and histopathologically examined.Results:Normal development and the closed neural tubes were shown in 18, 16, 13 and 9 embryos in groups 1 2, 3 and 9, respectively, of the 84 embryos incubated. Open neural tubes were found in one, three and five embryos in groups 2, 3 and 5, respectively. Also, developmental anomalies were found in three, four, five and seven embryos in groups 1, 2, 3 and 4, respectively. Moreover, no significant relationship between NTD and quetiapine exposure had been found.Conclusion:Quetiapine has no significant effect on the occurrence of neural tube defects in the chicken embryo model.

Corresponding author : Gokhan Canaz