Aim:Anterior cervical discectomy and fusion (ACDF) and cervical disc arthroplasty (CDA) are commonly employed cervical spine procedures for degenerative cervical spine pathology. However, patients may require a revision procedure, most commonly due to recurrence of same-level pathology, adjacent segment disease or hardware related complications. In the current study, we sought to utilize a national surgical quality registry to compare 30-day quality outcomes between repeat ACDF and CDAMaterial and Methods:The National Surgical Quality Improvement Project (NSQIP) Participant User Files (PUF) for the years 2005- 2018 was queried for patients undergoing repeat ACDF and CDA using current procedural terminology (CPT) and international classification of disease (ICD)-9th version codes. We compared demographic and baseline clinical characteristics, operative characteristics and 30-day readmissions, reoperations, and complications between the two groups. We also performed multivariable analyses to assess the impact of repeat procedure type on outcomes of interest.Results:A total of 3,957 patients were identified, of which 182 patients underwent a revision/removal of arthroplasty while 3,775 patients underwent revision or removal of fusion. Up to 4.6% patients (n=179) in the repeat ACDF group had a complication, compared to 0.5% (n=1) in the CDA group. The 30-day readmission rate was found to be similar between the two groups (repeat-ACDF: 3.8% (n=145), vs repeat-CDA: 2.2% (n=4); p=0.23). Similarly, the 30-day reoperation rate was also not found to be different between the two groups (repeat-ACDF: 3.9% (n=149) vs repeat-CDA: 2.7% (n=5);p=0.39). On multivariable analysis, removal or revision ACDF was only found to be significantly associated with an increased risk of 30-day complications (OR: 8.00, 95% CI: 1.07-59.79, p=0.04).Conclusion:Repeat ACDF or repeat CDA can be performed safely and are associated with optimal 30-day outcomes, comparable to those for index procedures. However, patients undergoing revision ACDF, compared to those undergoing revision CDA may be slightly more likely to have a complication.