Turkish Neurosurgery
Medulloblastoma: Clinicopathological correlates of SHH, WNT, and Non-WNT/SHH Molecular subgroups analysis and prognostic significance : Mono-institutional series
Bermal Hasbay1, Fazilet Kayaselçuk1, Halil İbrahim Suner2, Faik Sarıalioğlu3
1Başkent Universty Faculty of Medicine , Pathology, Adana,
2Başkent Universty Faculty of Medicine, Brain Surgery, Adana,
3Başkent Universty Faculty of Medicine, Pediatric Oncology, Adana,
DOI: 10.5137/1019-5149.JTN.34490-21.3

Aim:We reevaluated the medulloblastoma cases according to their histomorphological and molecular features and we aimed to investigate the relationship between the prognostic factors of the new WHO classification by applying Beta-catenin, YAP1, GAP1, P53, and INI1 antibodies immunohistochemically.Material and Methods:This study includes 41 patients who have been diagnosed as medulloblastoma between 2007-2019 in Pathology Department. Immunohistochemically, P53, Beta-catenin, YAP1, GAP1, and INI1 immune markers were applied and the relationship between the results and the prognostic parameters were evaluated statistically. Results:When 41 patients were divided into WHO medulloblastoma histological subtype groups according to histomorphological features:22 (53.7%) patients were classified as classical type, 11 (26.8%) patients as desmoplastic nodular type and 8 (19.5%) patients as large cell/anaplastic type medulloblastoma. According to their molecular characteristics, 14 (34.1%) patients were in the Non-WNT/SHH group, 5 (12.2%) patients were SHH mutant, 17 (41.5%) patients were SHH wild, and 5 (12.2%) patients were in the WNT active group. There was no statistically significant correlation between age, gender, tumor size, recurrence, Ki67 proliferation index with molecular types and histopathological types. Conclusion:In our study, metastasis at the time of diagnosis, histological large cell anaplastic type, immunohistochemical p53 positivity, molecular SHH mutant type were the statistically significant the indicators of worse prognosis and shorter survival time.

Corresponding author : Bermal Hasbay