Turkish Neurosurgery
Thyroxine speeds up functional recovery in a rat model of sciatic nerve crush
Fariba Mahmoudi2, Mozhdeh Azimpour1, Arash Abdolmaleki3, Abolfazl Bayrami4
1University of Mohaghegh Ardabili, Biology, ardabil,
2University of Mohaghegh Ardabili, Biology, ardabil,
3Sabalan University of Advanced Technologies, Biology, ardabil,
4University of Mohaghegh Ardabili, Biology, ardabil,
DOI: 10.5137/1019-5149.JTN.34966-21.4
Aim:The purpose of this study was to see how thyroxine affected the sensory and motor function of a damaged sciatic nerve in male rats.Material and Methods:FA total of forty adult male Wistar rats were separate to four groups with ten individuals. Then, crush injury was done on the right sciatic nerve In all groups using a vessel clamp. In thyroxine treatment groups after crush rats given regular doses of thyroxine (5 and 10 µg/kg) for one week intraperitoneally. Negative control group treated intraperitoneally with distilled water as a vehicle. And in sham operated group only surgical procedures was done without nerve crush. Then, behavioral, histological and morphometric parameters were assessed at the regeneration time.Results:After one week treatment with thyroxine the motor function improves significantly following a sciatic nerve crush (P ≤ 0.05). Also, morphometric parameters and sensory restoration improved in thyroxine treatment groups.Conclusion:Findings of this study showed that neuro-protective effects of thyroxine can be due to the stimulatory effects of thyroxine in myelin sheath formation and increasing the expression of SCG10 protein which is required for the development of growth cones.
Corresponding author : Fariba Mahmoudi