Turkish Neurosurgery
The alteration of neurogenesis and pathological markers in Alzheimer’s disease after deep brain stimulation
Behrad Nassehi1, Ersoy Kocabicak2, Yasin Temel 3, Sarah Hescham 3
1Ondokuz Mayıs University, Neuromodulation Center, Samsun,
2Ondokuz Mayıs University, Department of Neurosurgery, Samsun,
3Maastricht University Medical Center, Department of Neurosurgery, Mental Health and Neuroscience, Maastricht,
DOI: 10.5137/1019-5149.JTN.35598-21.2

Alzheimer’s disease (AD) is the most common type of dementia that causes disabilities in memory formation and activities of daily living. Unfortunately, pharmacologic treatments have minimal and short-lasting effects on the disease. With the increasing aging population, investigations into therapeutic strategies for AD that lead to delay in disease progression would significantly reduce the global burden of AD. Deep brain stimulation (DBS) is considered therapeutic for several conditions, such as movement disorders and some psychiatric diseases. Preclinical and clinical studies that used DBS as a treatment modality demonstrate the safety of DBS in AD and suggest potential memory improvements after surgery. Nevertheless, more studies are needed to understand the therapeutic mechanism of DBS. In this review, we summarize studies on DBS in various targets for AD and discuss DBS-induced changes in neurogenesis and pathological markers in AD.

Corresponding author : Ersoy Kocabicak