Aim:Pregnancy- and lactation-related osteoporosis (PLRO) is a rare transient osteoporosis causing severe low back pain and morbidity in the last trimester of pregnancy and in the postpartum period. The etiology of PLRO is still unclear. We aimed to share our experience regarding management and follow-up of patients with PLRO who were effectively treated. Material and Methods:In this case series, we presented 10 patients who were diagnosed with PLRO and treated from January 2010 to December 2020. VAS scale and laboratory findings were evaluated. Spinal and extremity magnetic resonance imaging (MRI) was obtained for patients with spinal and extremity pains. Dual energy X-ray absorptiometry was used for the measurement of bone mineral density. Values assessed on dual energy X-ray absorptiometry were L1-L4 T score, L2-L4 T score and femoral neck T score. Results:In the first-month follow-ups, all patients had meaningful pain relief and symptom resolution. The mean duration of pain control during the treatment period was 2.4 months. Two patients who continued breastfeeding were also the patients whose pain control was achieved at the latest. One patient required vertebroplasty surgery. Conclusion:Patients with PLRO should be promptly treated and followed-up. Discontinuation of breastfeeding will provide rapid advantage and should be the first step of the management. Early diagnosis and treatment of Calcium and Vitamin D with conservative procedures with spinal braces are very important for the treatment of PLRO patients. Additionally, bisphosphonates or teriparatide can improved the bone mineral density in patients with PLRO.