Aim:Peritumoral edema is one of the major causes of neurological function loss in primary or metastatic brain tumors. Magnetic resonance imaging modalities are the gold standard method used to evaluate cerebral tumor and peritumoral edema. In our study, we aimed to reveal the presence of SUR1/TRPM4 receptors in high-grade glial tumors and investigate its relationship with the volume of edema in preoperative MR sequences.Material and Methods:MRI sections were extracted from T1-weighted (T1W) and T2-weighted (T2W) sequences and FLAIR images. After that, T1W 3D Magnetization prepared rapid gradient echo (MPRAGE) (sequences with and without contrast medium). The tumor and peritumoral edema volume was calculated as cubic centimeters. SUR1/TRPM4 was studied by immunohistochemical examinations from tissue samples taken after surgery. Relationships between data were analyzed using the Spearman correlation coefficient.Results:In the immunohistochemical examination, SUR1 was positive in 58% of cases, and TRPM 4 was positive in 74% of cases at varying levels. All measured peritumoral and tumor volumes were correlated with each other. However, none of these volumetric measurements were correlated with SUR1/TRPM4 data. Conclusion:In our study, the presence of the SUR1–TRPM4 receptor complex was demonstrated in high-grade glial tumors. There is a need for many preclinical or clinical studies on the identification, validation and therapeutic contribution of SUR 1-TRPM4 in glial tumor subgroups.