Aim:Intracerebral hemorrhage (ICH) is a serious complication of neurosurgery associated with high mortality and disability. Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) is an endogenous RNA that competes with miR-181b in the regulation of central nervous system (CNS) biological activity. Ubiquitin C-terminal hydrolase L1 (UCH-L1), a downstream target of miR-181b, is a prominent biomarker for ICH.Material and Methods:In this study, we studied the lncRNA MEG3 and miR‐181b expression in 30 patients with ICH who were admitted to the General Hospital of Xinjiang Military Command from January 2021 to May 2021 by quantitative polymerase chain reaction. Serum levels of UCH-L1 were detected by enzyme‐linked immune sorbent assay, and disease severity was evaluated using the Glasgow Coma Scale. We also recorded ICH-related deaths in hospital. Results:In this study, we studied the lncRNA MEG3 and miR‐181b expression in 30 patients with ICH who were admitted to the General Hospital of Xinjiang Military Command from January 2021 to May 2021 by quantitative polymerase chain reaction. Serum levels of UCH-L1 were detected by enzyme‐linked immune sorbent assay, and disease severity was evaluated using the Glasgow Coma Scale. We also recorded ICH-related deaths in hospital. Conclusion:Our data indicated that lnc-MEG3, miR-181b, and UCH-L1 are likely involved in the pathophysiology of ICH, and could form the basis of future studies on potential targets for the treatment of traumatic CNS injuries. UCH-L1 could also find application in ICH management. Further studies on the plasma lncRNA-MEG3, miR-181b, and UCH-L1 levels in patients with ICH could yield novel biological targets for the prediction and treatment of ICH.