Aim:This study aimed to optimize the Spontaneous intracerebral hemorrhage (sICH) early hematoma expansion prediction scoring table based on the clinical data of sICH patients to adopt appropriate clinical treatment plans and improve the prognosis of sICH patients.Material and Methods:A total of 150 patients with sICH were enrolled, and 44 had early hematoma expansion. According to the selection and exclusion criteria, the study subjects were screened, their NCCT characteristic signs and clinical data were analyzed statistically, and the prediction score table was established. The established prediction score was applied to the follow-up study cohort to conduct a pilot study, and the t-test and ROC curve were used to evaluate its predictive ability.Results:Statistical analysis found that initial hematoma volume, GCS score, and NCCT special signs were independent risk factors for early hematoma expansion after sICH (P<0.05). Thus, a score table was established. Subjects with ≥10 were divided into high-risk group, 6-8 comprised the medium-risk group, and ≤4 were divided into low-risk group. Among 17 patients with acute sICH, 7 developed early hematoma enlargement. The prediction accuracy was 92.41% in the low-risk group, 98.06% in the medium-risk group, and 84.61% in the high-risk group. It shows the high prediction accuracy of the prediction rating table.Conclusion:This study established a sICH early hematoma expansion prediction score table based on the special signs of NCCT. This table has highly sensitive and accurate.