Background: Spondyloptosis in the thoracic region is a rare condition given its anatomical characteristics. Generally, spondyloptosis occurs after a high-output trauma. Trauma and infection can cause deformity in this region. Untreated spinal tuberculosis in 60% of the cases results in kyphosis. Case presentation: A 22-year-old female patient suddenly fell down because of lower extremity weakness. Spondyloptosis was observed, which developed following melting of the spine caused by tuberculosis. Successful reduction, spinal alignment, and stabilization of the spine were achieved following instrumentation with a long-segment screw and rod in a single-stage surgery. Conclusion: To the best of our knowledge, this is the first case of spondyloptosis secondary to tuberculosis. This case report highlights the treatment of spinal tuberculosis and surgical deformity correction in a single-stage surgery.