Turkish Neurosurgery
Cerebrolysin Ameliorates Spinal Cord Ischemia/Reperfursion Injury in a Rabbit Model
Caghan Tonge1, Pinar Kuru Bektasoglu2, Ahmet Gulmez1, Muhammed Erkan Emrahoglu1, M.Erhan Turkoglu1, Ata Turker Arikok3, Berrin İmge Erguder4, Mustafa Fevzi Sargon5, Bora Gurer6, Hayri Kertmen1
1University of Health Sciences, Dışkapı Education and Research Hospital, Department of Neurosurgery, Ankara,
2Sivas Numune Hospital, Department of Neurosurgery, Sivas,
3University of Health Sciences, Dışkapı Education and Research Hospital, Department of Pathology, Ankara,
4Ankara University School of Medicine, Department of Biochemistry, Ankara,
5Hacettepe University School of Medicine, Department of Anatomy, Ankara,
6Istinye University Faculty of Medicine, Department of Neurosurgery, İstanbul,
DOI: 10.5137/1019-5149.JTN.42362-22.6

Aim:Cerebrolysin is a well-known neuroprotective agent. This study investigated its effects on inflammation, oxidative stress, apoptosis, and neurologic recovery in the setting of spinal cord ischemia/reperfusion injury (SCIRI) in an experimental animal model.Material and Methods:Rabbits were randomly divided into five groups: control, ischemia, vehicle, methylprednisolone (30 mg/kg), and cerebrolysin (5 ml/kg) group. The rabbits in the control group underwent laparotomy; the other groups underwent spinal cord ischemia and reperfusion injury for 20 min. Neurologic examination after 24 h was based on the Modified Tarlov scale. Myeloperoxidase activities, catalase and malondialdehyde levels, and caspase-3 concentrations were determined in serum and tissue samples. Serum xanthine oxidase levels were studied and histopathological and ultrastructural changes were examined.Results:After SCIRI, serum and tissue myeloperoxidase activities, malondialdehyde levels, caspase-3 concentrations, and serum xanthine oxidase activities were increased (p<0.01–0.001). Catalase levels were significantly diminished (p<0.001). Cerebrolysin treatment correlated with reduced myeloperoxidase and xanthine oxidase activities, malondialdehyde levels and caspase-3 concentrations; and with increased catalase levels (p < 0.001, for all). The cerebrolysin group showed improved histopathological, ultrastructural, and neurological outcomes.Conclusion:For the first time in the literature the current study reports anti-inflammatory, antioxidant, antiapoptotic, and neuroprotective effects of cerebrolysin in a SCIRI rabbit model.

Corresponding author : Pinar Kuru Bektasoglu