Aim:The dynamic neutralization systems (Dynesys® and Orthrus®) was created as an alternative to spinal solid fixation to reduce adjacent segment disease and maintain physiologic motion and function in select cases. Besides the outcomes of dynamic stabilization in the multilevel degenerative spondylotic spine, the comparison of two dynamic systems with each other reveals the increasing role of dynamic systems in the management of the degenerative spine.Material and Methods:74 patients who received dynamic stabilization for degenerative pathologies were retrospectively analyzed. Demographic details: preoperative data including neurological status, pain scores, and radiology; and intraoperative data including blood loss, duration of surgery, complications, and postoperative data including the neurologic status, duration of hospital stay, and pain scores were examined.Results:Patients in both groups showed statistically significant improvements in their Visual Analog Scale and Oswestry Disability Index scores. Significant corrections of thoracic kyphosis (T2-T12), the sagittal vertical axis, and T10-L2 thoracolumbar kyphosis were obtained in our cohort (p < 0.05). A total of 4 patients received revision surgery due to screw loosening. Patients were discharged after 3–4 days and mobilized on the first postoperative day.Conclusion:We did not experience any serious issues in terms of stabilization in the cases in which we employed both systems. Our patient clinical results were satisfactory in both systems. Existing systems can be used safely even in long-segment stabilization surgeries.