Turkish Neurosurgery 2014 , Vol 24 , Num 1
Manic Episode Following Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson’s Disease: A Case Report
Tugce TOKER UGURLU1, Goksemin ACAR2, Filiz KARADAG1, Feridun ACAR3
1Pamukkale University, Faculty of Medicine, Department of Psychiatry, Denizli, Turkey
2Pamukkale University, Faculty of Medicine, Department of Neurology, Denizli, Turkey
3Pamukkale University, Faculty of Medicine, Department of Neurosurgery, Denizli, Turkey
DOI : 10.5137/1019-5149.JTN.7647-12.0 AIM: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapy for patients with Parkinson’s disease (PD) associated with motor complications of long term L-dopa treatment.

MATERIAL and METHODS: Here we report two cases with DBS- induced manic episode, focusing on the functional and anatomic correlates of psychiatric adverse effects of STN stimulation.

RESULTS: We present two cases of PD with motor complications due to long term L-dopa treatment that developed their first episodes of mania with psychotic symptoms after bilateral STN-DBS implantation. DBS-induced psychiatric adverse effects may be attributable either to limbic connections and STN-specific oscillations or stimulation of the medial forebrain bundle. Keywords : Deep brain stimulation, Subthalamic nucleus, Mania, Parkinson’s disease

Corresponding author : Tugce Toker Ugurlu, tugtoker@gmail.com