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Cerrahpaşa Medical Faculty University of İstanbul Turkey Vasospasm is the most important factor affecting morbidity and mortality in patients with subarachnoid haemorrhage. Many studies have been done and many factors found to affect vasospasm. The aim of this study is to clarify the factors by observing the ultrastructural effects of plasma and bilirubin on the basilar artery in dogs. Thirteen dogs of 13 - 17 kg were used in three groups using the suboccipital approach to group A (n:4) 5 ml of 10 day incubated blood containing plasma and erythrocytes to group B (n:5) 6 ml of one-day incubated autologous blood containing erythrocytes and bilirubin in concentrations equal to that of 10 - day incubated blood. and to group C (n:4) 5 ml saline were administered into the cisterna magna. At the end of 10 days the animals were sacrificed and basilar arteries were evaluated histologically. Morphological studies showed the presence of other factors in plasma which cause vasospasm apart from bilirubin. Keywords : Bilirubin, Cerebral vasospasm, Plasma