Turkish Neurosurgery 2024 , Vol 34 , Num 4
Paraoxonase 1 Activity and Phenotype Distribution in Lumbar Disc Herniation Patients
Utku ADILAY1,Nahit GENCER2,Kubra CIKRIKCI2,Muhammed Fatih SARI1,Emad Adden ABDALLAH1,Bulent GUCLU3
1Balikesir University, Faculty of Medicine, Department of Neurosurgery, Balikesir, Türkiye
2Balikesir University, Faculty of Science and Literature, Department of Chemistry, Balikesir, Türkiye
3Ministry of Health, Dr Lutfi Kırdar Kartal City Hospital, Neurosurgery Clinic, Istanbul, Türkiye
DOI : 10.5137/1019-5149.JTN.44307-23.2 AIM: To compare the Paraoxonase 1 (PON1) activity and phenotype distribution between lumbar disc herniation (LDH) patients and healthy individuals.

MATERIAL and METHODS: This research included 40 LDH patients and 42 healthy individuals. Spectrophotometric assays were performed to determine the serum PON1 and arylesterase activities. The PON1 ratio, which represents the salt-stimulated PON/ arylesterase level, demonstrated a trimodal distribution. This ratio was applied to identify the different phenotypes; QQ, QR, and RR of each subject.

RESULTS: The LDH patients had lower PON1 activity than the healthy individuals (p<0.05). LDH patients had a statistically significant QQ phenotype compared to the healthy subjects (p<0.05).

CONCLUSION: LDH patients had statistically lower PON1 activity, suggesting that the low PON1 activity and PON1 QQ phenotype may be a risk factor for LDH occurrence. Keywords : Lumbar disc herniation, Paraoxonase, Phenotype, PON1

Corresponding author : Utku ADILAY, utkuadilay@hotmail.com