Issue release date: 18.03.2025
2Hitit University, Faculty of Medicine, Department of Anatomy, Çorum, Türkiye
3Hitit University, Faculty of Arts and Sciences, Department of Chemistry, Çorum, Türkiye
4Private Neon Hospital, Department of Neurology, Erzincan, Türkiye
5Ordu University, Faculty of Medicine, Department of Neurosurgery, Ordu, Türkiye DOI : 10.5137/1019-5149.JTN.46057-23.7 AIM: To examine the effects of phenolic compound-rich ginger extract on motor and cognitive functions as well as cytokine levels in the mild traumatic brain injury (mTBI) model.
MATERIAL and METHODS: The mTBI model was modeled employing the Marmarou method. The Ginger group rats were i.p. administered 50 mg/kg of ginger extract. The Ginger+traumatic brain injury (TBI) group rats were i.p. administered 50 mg/kg of ginger extract two days before the TBI was induced. The control and TBI+Ginger group rats were provided ginger extract (50 mg/ kg i.p.) immediately after the TBI. Motor and cognitive behavioral experiments were performed. The cytokine levels were analyzed using the ELISA method.
RESULTS: While TBI caused a decline in motor and cognitive functions, significant enhancements of these functions were observed in the Ginger+TBI and TBI+Ginger groups because of the ginger treatment. While TBI induced an increased hippocampal cytokine level, significant decreases were detected in the Ginger+TBI and TBI+Ginger groups following ginger treatment.
CONCLUSION: The study findings revealed that phenolic compound-rich ginger extract may exert therapeutic effects on cytokine levels in the mTBI model.
Keywords : Ginger, Cognitive function, Neuroprotective treatment, Therapeutic treatment, Mild traumatic brain injury