The Impact of Hypertonic Dextrose on Dura Mater Regeneration and Fibroblast Activity Following Experimental Cerebrospinal Fluid Leakage

Omer SAHIN; Tuncer TASCIOGLU; Aysegul FIRAT; H. Selcuk SURUCU; Muzaffer CAYDERE; Duran Berker CEMIL

doi:10.5137/1019-5149.JTN.49101-25.3

Issue release date: 24.11.2025

Current Issue

Ahead Of Print

Archive

Subscription for Hardcopy

Turkish Neurosurgery 2025 , Vol 35 , Num 6

Abstract PDF Similar Articles Mail to Author

General Neurosurgery and Miscellaneous-Others - The Impact of Hypertonic Dextrose on Dura Mater Regeneration and Fibroblast Activity Following Experimental Cerebrospinal Fluid Leakage

Omer SAHIN¹,Tuncer TASCIOGLU²,Aysegul FIRAT³,H. Selcuk SURUCU⁴,Muzaffer CAYDERE⁵,Duran Berker CEMIL²

¹Bestepe State Hospital, Department of Neurosurgery, Ankara, Türkiye
²University of Health Sciences, Ankara Training and Research Hospital, Department of Neurosurgery, Ankara, Türkiye
³Hacettepe University Faculty of Medicine, Department of Anatomy, Ankara, Türkiye
⁴Koc University Faculty of Medicine, Department of Anatomy, Istanbul, Türkiye
⁵University of Health Sciences, Ankara Training and Research Hospital, Department of Pathology, Ankara, Türkiye DOI : 10.5137/1019-5149.JTN.49101-25.3 AIM: To investigate the effects of 25% dextrose in a rat model of cerebrospinal fluid leakage.

MATERIAL and METHODS: Forty Wistar rats were included in the study. The dura mater of the rats was opened, and 25% dextrose was applied topically at a dose of 0.1 ml. Rats were sacrificed at the end of the third and sixth weeks. Then, pathologic and electron microscopic evaluations were performed.

RESULTS: The results of healing score and fibroblast density evaluations showed that dextrose led to more successful healing than control subjects in early and late postoperative evaluations. In addition, electron microscopic examination showed that fibroblasts had active endoplasmic reticulum and mitochondria in a large cytoplasm, indicating increased collagen secretion.

CONCLUSION: After dura mater injury, 25% dextrose, a cheap and accessible agent, has the potential to be used to enhance healing. Keywords : Hypertonic glucose, Wound healing, Rat, Cerebrospinal fluid leak

Corresponding author : Omer SAHIN, dromersahin060@gmail.com