Turkish Neurosurgery 2020 , Vol 30 , Num 4
The Analysis of Safety and Effectiveness Using Allograft in the Treatment of Spinal Tuberculosis-A Multicenter Retrospective Study
Sen YANG1,Hongwei LU1,Fei LUO1,Zehua ZHANG1,Wenjie WU1
1Third Military Medical University, Southwest Hospital, Department of Orthopaedics, Chongqing, China DOI : 10.5137/1019-5149.JTN.27503-19.3 AIM: To evaluate the clinical efficacy and fusion characteristics of allografts in spinal tuberculosis (TB).

MATERIAL and METHODS: The research reviewed 1196 patients with spinal tuberculosis who received treatment at six hospitals from January 2000 to January 2016. A total of 623 patients who had spinal tuberculosis were included in the study. All patients underwent debridement, decompression, allograft bone grafting, and instrumentation. Postoperative treatment consisted of a combination of anti-TB drug treatment for 18 months and brace fixed braking for 3?9 months. Clinical outcome, laboratory indexes, and radiological results were analysed.

RESULTS: The average follow-up time was 34.1 months (12?60 months). Pain was relieved postoperatively in all cases, and 87.8% of patients were painless at the final follow-up. The erythrocyte sedimentation rate (ESR) significantly decreased and returned to normal at the final follow-up. The fusion rate of allografts was 30.2% and 98.4% at the 9- and 12-month follow-ups, respectively. At the final follow-up, the fusion rate was 100%.

CONCLUSION: The application of allografts in the surgical management of spinal tuberculosis is safe and effective. Allografts can replace autografts in surgeries for spinal tuberculosis. Keywords : Allograft, Fusion, Spinal tuberculosis

Corresponding author : Wenjie WU, bisheng320@126.com