Magnesium Acetyl Taurate Prevents Tissue Damage and Deterioration of Prosocial Behavior Related with Vasopressin Levels in Traumatic Brain Injured Rats

Ferda HOSGORLER; Basar KOC; Servet KIZILDAG; Selin CANPOLAT; Asuman ARGON; Asli KARAKILIC; Sevim KANDIS; Guven GUVENDI; Mehmet ATES; Nuri M. ARDA; Nazan UYSAL

doi:10.5137/1019-5149.JTN.29272-20.1

Issue release date: 08.03.2024

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Turkish Neurosurgery 2020 , Vol 30 , Num 5

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Magnesium Acetyl Taurate Prevents Tissue Damage and Deterioration of Prosocial Behavior Related with Vasopressin Levels in Traumatic Brain Injured Rats

Ferda HOSGORLER¹,Basar KOC¹,Servet KIZILDAG²,Selin CANPOLAT³,Asuman ARGON³,Asli KARAKILIC¹,Sevim KANDIS¹,Guven GUVENDI¹,Mehmet ATES²,Nuri M. ARDA⁴,Nazan UYSAL¹

¹Dokuz Eylul University, School of Medicine, Department of Physiology, Izmir, Turkey
²Dokuz Eylül University, School of Medicine, College of Vocational School of Health Services, Izmir, Turkey
³Ministry of Health Bozyaka Training and Research Hospital, Department of Pathology, Izmir, Turkey
⁴Dokuz Eylul University, School of Medicine, Department of Neurosurgery, Izmir, Turkey DOI : 10.5137/1019-5149.JTN.29272-20.1 AIM: To investigate the effects of different magnesium forms on tissue damage, cognitive and emotional behavioural impairment after mild traumatic brain injury (TBI).

MATERIAL and METHODS: Rats were divided into 5 groups (control, trauma, magnesium sulphate, magnesium citrate, magnesium acetyl taurate) and following head trauma, empathy-like behaviour, anxiety-like behaviour (elevated plus maze and open field tests), and depression (forced swim test) were measured. The rats were then sacrificed 12 days later. Oxytocin, vasopressin and receptors levels in the amygdala and prefrontal cortex regions were measured. Histopathological damage (with haematoxylin-eosin staining) and apoptosis (with caspase-3 immunohistochemistry) was evaluated.

RESULTS: Following head trauma, anxiety-like behaviour and depression tests did not change; empathy-like behaviour deteriorated on the 3rd day and improved gradually on the 6th and 12th days. Oxytocin, vasopressin and vasopressin v1b receptor levels decreased in the amygdala; morphological damage and apoptosis were significant. Magnesium acetyl taurate effectively ameliorated histopathological deteriorations and improved vasopressin and v1b receptor levels in the amygdala. Transient deterioration of empathy-like behaviour was impeded only in magnesium taurate treatment.

CONCLUSION: Magnesium acetyl taurate can be a promising candidate agent to prevent structural and functional damage in traumatic brain injury. Keywords : Traumatic brain injury, Magnesium, Empathy, Vasopressin, Vasopressin v1b receptor, Rat

Corresponding author : Ferda HOSGORLER, ferda.hosgorler@deu.edu.tr