Aim:Surgery remains the primary treatment for parasagittal meningiomas (PSM). Given that most surgical series assess individuals from a functional point of view, the quality of life (QoL) among these patients has been poorly evaluated. The present study aims to assess QoL in patients with PSM and identify risk factors for different levels of QoLMaterial and Methods:Patients were contacted and interviewed via telephone. A total of 136 patients with PSM underwent surgery at our institution between 1984 and 2020. Among them, 45 had agreed to participate in the research. The scales utilized included the Functional Assessment of Cancer Therapy General (FACT-G), Brain (FACT-Br), and Meningioma (FACT-MNG). Medical records were also reviewed.Results:The mean KPS was 93.3 (70–100). Overall, the mean scores for the FACT-G, FACT-Br, and FACT-MNG scales were 98.4/108 (55–108; SD: 12.9), 179.3/200 (98–200; SD: 22.4), and 219.3 (119–248; SD: 29.7). Considerable variability in scales scores was observed among those with the same KPS score. Preoperative KPS score was significantly associated with both FACT-Br [−21.64; 95% CrI (−34.04, −9.59)] and FACT-MNG [−31.88; 95% CrI (−47.24, −15.25)]. Preoperative KPS was identified as a risk factor for QoL impairment.Conclusion:Variability in the scale scores among those with the same KPS score highlights the importance of structured assessment. Moreover, KPS may overlook impairments in QoL. To date, this has been the first study to assess QoL in PSM patients.