Aim: Intraparenchymal hemorrhage (IPH) is a severe neurological disease defined by unexpected bleeding within brain tissue, with a high mortality and morbidity rate. The COVID-19 pandemic has lately afflicted millions of people globally and has emerged as a new and potentially dangerous trigger for IPH. The present study investigates the possible association between COVID-19 infection and IPH by examining changes in the preoperative and postoperative periods, mortality, and the impact of COVID-19 on IPH survival times.Material and Methods:This cross-sectional retrospective analysis included 82 IPH cases operated on and treated between January 2021 and March 2023. Brain computed tomography/magnetic resonance imaging scans were used to confirm the diagnosis of IPH and provide evidence of neurological damage. The information was gathered using a predesigned form of hospital records. Participants were included if they had a positive COVID-19 result or displayed no symptoms, indicating a past infection.Results:The study included 82 people, nine (11%) tested positive for COVID-19, and 73 (89%) tested negative. The two groups had no difference in mortality rates (p=0.651). The hematoma volume decreased from the preoperative (82.4±42.4) to the postoperative (23.7±44.8) measurement (p<0.001). The midline shift value decreased from the preoperative (9.26±4.71) to the postoperative (5.16 ± 5.06) assessment (p<0.001). Patients without COVID-19 infection had a mean survival time of 31.5 days and a median survival time of 23 days, whereas patients with COVID-19 infection had a survival time of 25.7 days and a median survival time of 8 days.Conclusion:Our findings show that hematoma volume and midline shift improve significantly after surgery, although GCS scores remain unaltered. Except for AST and ALT levels, there were no significant differences in mortality rates, demographic, clinical, and most laboratory results between COVID-19-positive and COVID-19-negative patients.