Aim:Myelomeningocele (MMC) is a type of spinal dysraphism that usually occurs in 1 out of 1,000 live births. The majority of patients with MMC experience hydrocephalus. Furthermore, it is usual to observe concurrent abnormalities in the central nervous system. Individuals with meningomyelocele-linked hydrocephalus have a lower incidence of epilepsy compared to those with hydrocephalus due to other factors. The objective of this study was to examine the prevalence of epilepsy and other associated cortical abnormalities in patients with MMC and to provide our findings along with a review of the literature.Material and Methods:A retrospective analysis was conducted using file records from our pediatric neurology outpatient clinic. We reviewed the records of MMC patients who attended our outpatient clinic between 2015 and 2020. Results:The study included a total of 23 patients. The ages ranged between 7 months and 19 years, and the median follow-up period was 36 months. We found the incidence of epilepsy to be 43.5% (n = 10). Hydrocephalus was present in 20 (87%) patients. Concomitant central nervous system anomalies were present in 18 (78.3%) of the patients. We diagnosed epilepsy in 52.6% of the cases with a ventriculoperitoneal shunt, but not in any of the cases without a shunt.Conclusion:Our study revealed a greater incidence of epilepsy among patients with MMC, in contrast to the current state of the literature. As the life expectancy of patients with MMC increases over time, secondary clinical manifestations such as epilepsy may become more evident. Furthermore, the majority of research on the prevalence of epilepsy and seizures among individuals diagnosed with MMC took place approximately two decades ago. Further extensive research should be undertaken to examine the changing incidence.