Turkish Neurosurgery 2013 , Vol 23 , Num 2
Brown Tumors of the Anterior Skull Base as the Initial Manifestation of True Normocalcemic Primary Hyperparathyroidism: Report of Three Cases and Review of the Literature
Mahmoud Reza KHALATBARI1, Mehrdokht HAMIDI1, Yashar MOHARAMZAD1, Ali SETAYESH2, Abbas AMIRJAMSHIDI3
1Arad Hospital, Department of Neurosurgery, Tehran, Islamic Republic of Iran
2Hazrate-Rasoul Hospital, Department of General Surgery, Tehran, Islamic Republic of Iran
3Sina Hospital, Department of Neurosurgery, Tehran, Islamic Republic of Iran
DOI : 10.5137/1019-5149.JTN.4504-11.2 Brown tumor is a bone lesion secondary to hyperparathyroidism of various etiologies. Skeletal involvement in primary hyperparathyroidism secondary to parathyroid adenoma is very uncommon and brown tumor has become extremely a rare clinical entity. Hyperparathyroidism is usually associated with high levels of serum calcium. Brown tumor as the only and initial symptom of normocalcemic primary hyperparathyroidism is extremely rare. Moreover, involvement of the skull base and the orbit is exceedingly rare. The authors would report three cases of brown tumor of the anterior skull base that were associated with true normocalcemic primary hyperparathyroidism. Clinical manifestations, neuroimaging findings, pathological findings, diagnosis and treatment of the patients are discussed and the relevant literature is reviewed. Keywords : Brown tumor, Skull base, Normocalcemia, Primary hyperparathyroidism
Corresponding author : Mahmoud Reza Khalatbarř, mrkhalatbari@hotmail.com