Issue release date: 18.03.2025
Turkish Neurosurgery
2014 , Vol 24 , Num 5
1Bulent Ecevit University, School of Medicine, Department of Pathology, Zonguldak, Turkey
2Bulent Ecevit University, School of Medicine, Department of Neurosurgery, Zonguldak, Turkey DOI : 10.5137/1019-5149.JTN.8057-13.1 Glomeruloid microvascular proliferation (GMP) is a localized proliferation of vascular endothelial cells resembling a renal glomerule. The nature of cells participating in the formation of these structures remains unclear. While it is a characteristic feature of glioblastoma, it is rarely seen in other solid tumors. Presence of diffuse GMP in meningiomas is characterized by peritumoral edema and an atypical contrast uptake in radiological imaging. Due to its rare nature, a case of spinal meningioma comprising distinct GMP was presented in this study in company with literature data. Also provided a discussion on the pathogenesis of this unusual pattern of angiogenesis and its relationship with tumors biological behavior. Keywords : Meningioma, Glomeruloid microvascular proliferation, Angiogenesis, VEGF
Corresponding author : Nilüfer Onak Kandemır
2Bulent Ecevit University, School of Medicine, Department of Neurosurgery, Zonguldak, Turkey DOI : 10.5137/1019-5149.JTN.8057-13.1 Glomeruloid microvascular proliferation (GMP) is a localized proliferation of vascular endothelial cells resembling a renal glomerule. The nature of cells participating in the formation of these structures remains unclear. While it is a characteristic feature of glioblastoma, it is rarely seen in other solid tumors. Presence of diffuse GMP in meningiomas is characterized by peritumoral edema and an atypical contrast uptake in radiological imaging. Due to its rare nature, a case of spinal meningioma comprising distinct GMP was presented in this study in company with literature data. Also provided a discussion on the pathogenesis of this unusual pattern of angiogenesis and its relationship with tumors biological behavior. Keywords : Meningioma, Glomeruloid microvascular proliferation, Angiogenesis, VEGF